The biggest difference is that the effects section now features two slots, each offering Chorus, Delay, Reverb, Flanger, Phaser and Lo-Fi effects - this is greatly preferable to Toxic III's rather limited delay and chorus effects. In fact, Toxic owners won't find a lot of new ideas here either, but there are a few new additions that make it an overall better synth. If you're already au fait with either of Native Instruments' FM synths or LinPlug and Maxx Claster's own Octopus, there's not much here that you won't have seen before. The catch is that Biohazard's frequency modulation is less sophisticated than some of its competitors', and it's not possible for oscillators to modulate themselves. As such, it's a cinch to dive right in and start creating sounds, and even those who haven't used an FM synth before should find it easy to get to grips with. The modulation display packs an awful lot into a small space without feeling fiddly or cramped, and is certainly a lot more inviting than FM8's noob-scaring plethora of pages.